Nanoformulation of Premixing Propofol Lipid Emulsion and Fentanyl Citrate and Their Effects on Acute Toxicity, Sedation, and Analgesia

Figure 5

TEM micrographs of propofol lipid emulsion, fentanyl citrate, mixture of propofol lipid emulsion and fentanyl citrate, and mixture of propofol lipid emulsion and physiological saline. (a) Propofol lipid emulsion. (b–f) Mixed propofol lipid emulsion and fentanyl citrate (volume ratios of 20 : 1, 20 : 2, 20 : 3, 20 : 4, and 20 : 5). The arrow pointed to ~10 nm fusiform particles at the juncture of 200–300 nm particles. (g-h) Mixed propofol and physiological saline (volume ratios of 20 : 2 and 20 : 5). (i) Fentanyl citrate.

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