Nanoformulation of Premixing Propofol Lipid Emulsion and Fentanyl Citrate and Their Effects on Acute Toxicity, Sedation, and Analgesia

Table 1

Acute toxicity, sedation, and analgesia test in the individual and premixed groups of propofol lipid emulsion and fentanyl citrate.

		Acute toxicity test		Sedation test		Analgesia test
		LD50	CI 95%	ED50	CI 95%	ED50	CI 95%
Individual group	Propofol (mg/kg)	34.84	27.68, 43.30	7.31	5.98, 12.30	7.30	5.85, 7.31
	Fentanyl (µg/kg)	17.42	13.84, 21.65	3.36	2.99, 6.15	3.65	2.93, 3.66
Premixed group	Propofol (mg/kg)	34.84	29.46, 47.00	5.85	4.78, 9.94	3.74	2.95, 4.69
	Fentanyl (µg/kg)	17.42	14.73, 23.50	2.93	2.39, 4.97	1.87	1.48, 2.19

Median lethal dose (LD₅₀), median effective dose (ED₅₀), and 95% confidence interval (CI 95%). < 0.05 between groups.