One-Step Electrosynthesis of Graphene Oxide-Doped Polypyrrole Nanocomposite as a Nanointerface for Electrochemical Impedance Detection of Cell Adhesion and Proliferation Using Two Approaches

Figure 9

Cell adhesion and proliferation behaviors on GO/PPy-ITO microelectrodes measured by non-Faraday electrochemical impedance spectroscopy. (a) Typical Bode plot of electrochemical impedance spectra of bare ITO and GO/PPy-ITO microelectrodes recorded at 0 h, 2 h, 24 h, 48 h, and 72 h after inoculation of A549 cells. (b) Typical phase plot of electrochemical impedance spectra of bare ITO and GO/PPy-ITO microelectrodes recorded at 0 h, 2 h, 24 h, 48 h, and 72 h after inoculation of A549 cells. (c) Equivalent circuit model of the GO/PPy-ITO microelectrode (left) and equivalent circuit model of the cells (right) in series. (d) Curve fit results for the equivalent circuit model of A549 cells after inoculation on GO/PPy-ITO microelectrodes at different times.

(a)

(b)

(c)

(d)