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Journal of Nanomaterials
Volume 2016, Article ID 8970213, 12 pages
http://dx.doi.org/10.1155/2016/8970213
Research Article

Medicated Nanofibers Fabricated Using NaCl Solutions as Shell Fluids in Modified Coaxial Electrospinning

1Department of Mechanical Engineering, Guangxi Technological College of Machinery and Electricity, Nanning 530007, China
2School of Material Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China

Received 4 December 2015; Accepted 22 March 2016

Academic Editor: Marco Salerno

Copyright © 2016 Yong-Hui Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The present study reports the fabrication of medicated nanofibers for potential colon-targeted drug delivery using modified coaxial electrospinning, in which salt (NaCl) solutions were exploited as shell fluids to facilitate the preparation processes. A homemade concentric spinneret with an indented core capillary was developed to conduct the coaxial processes. Optical observations and scanning electron microscopic results demonstrated that the shell-to-core fluid flow rate ratio was a key parameter, which exerted a significant influence on the electrospinning processes and could be exploited to control the fibers’ morphology and diameters. A scaling law of () was built, by which the nanofibers’ sizes can be predicted and manipulated easily. X-ray diffraction and attenuated total reflected FTIR tests verified that the medicated nanofibers were essentially a polymeric nanocomposite and the guest drug diclofenac sodium (DS) had fine compatibility with the host polymer. All the drug was encapsulated in the filament-forming carrier. In vitro dissolution experiments demonstrated that the medicated nanofibers could free the drug in a neutral condition, suggesting potential colon-targeted drug delivery applications. Ex vivo tests demonstrated that the medicated fiber mats could enhance the transmembrane of DS. Based on coaxial electrospinning, a new strategy is successfully developed for creating medicated nanomaterials.