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Journal of Nanomaterials
Volume 2016, Article ID 9505704, 8 pages
Research Article

Characterization of Silver Nanoparticle In Situ Synthesis on Porous Sericin Gel for Antibacterial Application

1State Key Laboratory of Silkworm Genome Biology, Southwest University, Beibei, Chongqing 400715, China
2Chongqing Engineering and Technology Research Center for Novel Silk Materials, College of Biotechnology, Southwest University, Beibei, Chongqing 400715, China
3College of Pharmaceutical Sciences, Southwest University, Beibei, Chongqing 400715, China
4National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China

Received 26 December 2015; Accepted 11 April 2016

Academic Editor: Liangliang Hao

Copyright © 2016 Gang Tao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Sericin from Bombyx mori cocoon has good hydrophilicity, reaction activity, biocompatibility, and biodegradability, which has shown great potentials for biomedical materials. Here, an ultraviolet light-assisted in situ synthesis approach is developed to immobilize silver nanoparticles on the surface of sericin gel. The amount of silver nanoparticles immobilized on the surface of sericin gel could be regulated by the irradiation time. The porous structure and property of sericin gel were not affected by the modification of AgNPs, as evidenced by the observation of scanning electron microscopy, X-ray diffractometry, and Fourier transform infrared spectroscopy. Differential scanning calorimetry analysis showed that the modification of AgNPs increased the thermal stability of sericin gel. The growth curve of bacteria and inhibition zone assays suggested that the sericin gel modified with AgNPs had good antimicrobial activities against both Gram-negative and Gram-positive bacteria. This novel sericin has shown a great potential for biomedical purpose.