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Journal of Nanomaterials
Volume 2017 (2017), Article ID 1980714, 14 pages
Research Article

Comparative Study of One-Step Cross-Linked Electrospun Chitosan-Based Membranes

1Laboratorio de Nanobiotecnología, MICRONA, Universidad Veracruzana, 94294 Boca del Río, VER, Mexico
2Facultad de Ciencias Físico-Matemáticas, Benemérita Universidad Autónoma de Puebla, 72570 Puebla, PUE, Mexico
3Facultad de Bioanálisis, Universidad Veracruzana, 91700 Veracruz, VER, Mexico

Correspondence should be addressed to C. Mendoza-Barrera

Received 3 March 2017; Revised 27 May 2017; Accepted 5 June 2017; Published 6 July 2017

Academic Editor: Russell E. Gorga

Copyright © 2017 Yanet E. Aguirre-Chagala et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Chitosan membranes are widely applied for tissue engineering; however, a major drawback is their low resistance in aqueous phases and therefore the structure collapses impeding their long-term use. Although there is extensive research, because of chitosan’s importance as a biomaterial, studies involving chitosan-based membranes are still needed. Herein, a detailed investigation of diverse chemical routes to cross-link fibers in situ by electrospinning process is described. In case of using genipin as cross-linker, a close relationship with the content and the mean diameter values is reported, suggesting a crucial effect over the design of nanostructures. Also, the physical resistance is enhanced for the combination of two types of methods, such as chemical and physical methods. Cross-linked fibers upon exposure to long wave ultraviolet A (UVA light) change their morphology, but not their chemical composition. When they are incubated in aqueous phase for 70 days, they show an extensive improvement of their macrostructural integrity which makes them attractive candidates for tissue engineering application. As a result, the thermal properties of these materials reveal less crystallinity and higher temperature of degradation.