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Journal of Nanomaterials
Volume 2017, Article ID 3282693, 7 pages
https://doi.org/10.1155/2017/3282693
Research Article

Formulation and Characterization of Hydroquinone Nanostructured Lipid Carriers by Homogenization Emulsification Method

1Department of Cosmetic Science, Providence University, Taichung, Taiwan
2Department of Applied Chemistry, Providence University, Taichung, Taiwan

Correspondence should be addressed to Chih-Chien Lin; wt.ude.up@nilhchc

Received 5 January 2017; Revised 24 April 2017; Accepted 4 May 2017; Published 1 June 2017

Academic Editor: Takuya Tsuzuki

Copyright © 2017 Pey-Shiuan Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Nanostructured lipid carrier (NLC) was prepared by homogenization emulsification method and improved with modified surfactants. The properties of nanoparticles were investigated using the NLC system for hydroquinone (HQ) as a model drug and by increasing the light stability of hydroquinone. The optimized condition of NLC in stirring was 1200 rpm, the homogenized speed was 8000 rpm, solid oil to liquid oil ratio was 3 : 7, and lecithin to surfactant ratio was 3 : 1. The particle size was  nm and the encapsulation efficiency was %. The zeta-potential of HQ-NLC was better than −30 mV. In the thermogravimetric analysis (TGA) studies, adding of PLANTACARE 2000 UP for HQ-NLC has better heat resisting property than the HQ-NLC only. The addition of PLANTACARE 2000 UP to NLC shows better permeability (125.10%) than that of Blank. In the stability studies, the HQ-NLC after UVA/UVB irradiation has better inhibition rate (34.25%) than that of the Blank. In the present study, NLC system has successfully improved the light stability and the skin permeability of active compound. Therefore, the NLC might be a potential delivery vehicle for transdermal products in the future.