Polymalic Acid Tritryptophan Copolymer Interacts with Lipid Membrane Resulting in Membrane Solubilization

Figure 2

Solubilization of lipid by PMLA copolymers. (a) After preparative separation from large aggregates through 0.2 μm pore size filters, multilamellar vesicle (MLV) of Egg PC (L-α-phosphatidylcholine) was incubated with the PMLA copolymers (vials from left to right, P/WWW, P/LLL, P/LOEt, and MLV only). The suspensions were then agitated by vortex and sonication under identical conditions. All vials remained turbid except for the added P/WWW (liposome/copolymer weight ratio, 2 : 1). (b) The hydrophobic diameter of the particles formed in the clear mixture of P/WWW and membrane was  nm by dynamic light scattering.

(a)

(b)