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Journal of Nanomaterials
Volume 2017, Article ID 6796412, 7 pages
https://doi.org/10.1155/2017/6796412
Research Article

Synthesis, Characterization, and Drug Delivery from pH- and Thermoresponsive Poly(N-Isopropylacrylamide)/Chitosan Core/Shell Nanocomposites Made by Semicontinuous Heterophase Polymerization

1Departamento de Ingenieria Mecanica Electrica, Universidad de Guadalajara, Boul. M. García-Barragán #1451, 44430 Guadalajara, JAL, Mexico
2Ingeniería Química, Universidad de Guadalajara, Boul. M. García-Barragán #1451, 44430 Guadalajara, JAL, Mexico
3Física, Universidad de Guadalajara, Boul. M. García-Barragán #1451, 44430 Guadalajara, JAL, Mexico
4Centro de Investigación en Química Aplicada, Av. Ing. E. Reyna #140, 25294 Saltillo, COAH, Mexico

Correspondence should be addressed to Jorge E. Puig; xm.gdu.liam@ejgiup

Received 31 August 2016; Revised 16 December 2016; Accepted 19 December 2016; Published 24 January 2017

Academic Editor: Xuping Sun

Copyright © 2017 Abraham G. Alvarado et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Langer and D. A. Tirrell, “Designing materials for biology and medicine,” Nature, vol. 428, no. 6982, pp. 487–492, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. F. Alexis, E. Pridgen, L. K. Molnar, and O. C. Farokhzad, “Factors affecting the clearance and biodistribution of polymeric nanoparticles,” Molecular Pharmaceutics, vol. 5, no. 4, pp. 505–515, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. Z. Liu, Y. Jiao, Y. Wang, C. Zhou, and Z. Zhang, “Polysaccharides-based nanoparticles as drug delivery systems,” Advanced Drug Delivery Reviews, vol. 60, no. 15, pp. 1650–1662, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. N. S. Rejinold, P. R. Sreerekha, K. P. Chennazhi, S. V. Nair, and R. Jayakumar, “Biocompatible, biodegradable and thermo-sensitive chitosan-g-poly (N-isopropylacrylamide) nanocarrier for curcumin drug delivery,” International Journal of Biological Macromolecules, vol. 49, no. 2, pp. 161–172, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. A. D. Sezer and E. Cevher, “Topical drug delivery using chitosan nano- and micro-particles,” Expert Opinion on Drug Delivery, vol. 9, no. 9, pp. 1129–1146, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. G. Berth, A. Voigt, H. Dautzenberg, E. Donath, and H. Möhwald, “Polyelectrolyte complexes and layer-by-layer capsules from chitosan/chitosan sulfate,” Biomacromolecules, vol. 3, no. 3, pp. 579–590, 2002. View at Publisher · View at Google Scholar · View at Scopus
  7. Y. Hu, X. Jiang, Y. Ding, H. Ge, Y. Yuan, and C. Yang, “Synthesis and characterization of chitosan-poly(acrylic acid) nanoparticles,” Biomaterials, vol. 23, no. 15, pp. 3193–3201, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. Y. Hu, Y. Ding, D. Ding et al., “Hollow chitosan/poly(acrylic acid) nanospheres as drug carriers,” Biomacromolecules, vol. 8, no. 4, pp. 1069–1076, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. C. Choi, J.-P. Nam, and J.-W. Nah, “Application of chitosan and chitosan derivatives as biomaterials,” Journal of Industrial and Engineering Chemistry, vol. 33, pp. 1–10, 2016. View at Publisher · View at Google Scholar · View at Scopus
  10. P. K. Dutta, Ed., Chitin and Chitosan for Regenerative Medicine, Springer Series of Polymer and Composite Materials, Springer, New York, NY, USA, 2016.
  11. A. Yamada, Y. Hiruta, J. Wang, E. Ayano, and H. Kanazawa, “Design of environmentally responsive fluorescent polymer probes for cellular imaging,” Biomacromolecules, vol. 16, no. 8, pp. 2356–2362, 2015. View at Publisher · View at Google Scholar · View at Scopus
  12. Y. Isikver and D. Saraydin, “Environmentally sensitive hydrogels: N-isopropylacrylamide/acrylamide/mono-, di-, tricarbixylic acid crosslinked polymers,” Polymer Engineering and Science, vol. 55, no. 4, pp. 843–851, 2014. View at Publisher · View at Google Scholar
  13. F. Sun, Y. Wang, Y. Wei, G. Cheng, and G. Ma, “Thermo-triggered drug delivery from polymeric micelles of poly(N-isopropylacrylamide-co-acrylamide)-b-poly(n-butyl methacrylate) for tumor targeting,” Journal of Bioactive and Compatible Polymers, vol. 29, no. 4, pp. 301–317, 2014. View at Publisher · View at Google Scholar · View at Scopus
  14. H. G. Schild, “Poly(N-isopropylacrylamide): experiment, theory and application,” Progress in Polymer Science, vol. 17, no. 2, pp. 163–249, 1992. View at Publisher · View at Google Scholar · View at Scopus
  15. C.-H. Huang, C.-F. Wang, T.-M. Don, and W.-Y. Chiu, “Preparation of pH- and thermo-sensitive chitosan-PNIPAAm core–shell nanoparticles and evaluation as drug carriers,” Cellulose, vol. 20, no. 4, pp. 1791–1805, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. Wang, H. Xu, L. Ge, and J. Zhu, “Development of a thermally responsive nanogel based on chitosan-poly(N-isopropyl-co-acrylamide) for paclitaxel delivery,” Pharmaceutics, Drug Delivery and Pharmaceutical Technology, vol. 103, pp. 2012–2021, 2014. View at Google Scholar
  17. A. Popat, J. Liu, G. Q. Lu, and S. Z. Qiao, “A pH-responsive drug delivery system based on chitosan coated mesoporous silica nanoparticles,” Journal of Materials Chemistry, vol. 22, no. 22, pp. 11173–11178, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. T. Chang, P. Gosain, M. H. Stenzel, and M. S. Lord, “Drug loading of poly[(polyethylene glycol methyl ether methacrylate)-block-poly(methyl methacrylate)] (PEGMEMA)-based micelles and mechanisms of uptake in colon carcinoma cells,” Colloid and Surfaces B—Biointerfaces, vol. 144, pp. 257–264, 2016. View at Google Scholar
  19. J. Li, D. Liu, G. Tan, Z. Zhao, X. Yang, and W. Pan, “A comparative study on the efficiency of chitosan-N-acetylcysteine, chitosan oligosaccharides or carboxymethyl chitosan surface modified nanostructured lipid carrier for ophthalmic delivery of curcumin,” Carbohydrate Polymers, vol. 146, pp. 435–444, 2016. View at Publisher · View at Google Scholar · View at Scopus
  20. R. Onnainty, B. Onida, P. Páez, M. Longhi, A. Barresi, and G. Granero, “Targeted chitosan-based bionanocomposites for controlled oral mucosal delivery of chlorhexidine,” International Journal of Pharmaceutics, vol. 509, no. 1-2, pp. 408–418, 2016. View at Publisher · View at Google Scholar · View at Scopus
  21. G. A. F. Roberts and J. G. Domszy, “Determination of the viscometric constants for chitosan,” International Journal of Biological Macromolecules, vol. 4, no. 6, pp. 374–377, 1982. View at Publisher · View at Google Scholar · View at Scopus
  22. J. Aguilar, F. Moscoso, O. Rios et al., “Swelling behavior of poly(N-isopropylacrylamide) nanogels with narrow size distribution made by semi-continuous inverse heterophase polymerization,” Journal of Macromolecular Science, Part A: Pure and Applied Chemistry, vol. 51, no. 5, pp. 412–419, 2014. View at Publisher · View at Google Scholar · View at Scopus
  23. T. López-León, E. L. S. Carvalho, B. Seijo, J. L. Ortega-Vinuesa, and D. Bastos-González, “Physicochemical characterization of chitosan nanoparticles: electrokinetic and stability behavior,” Journal of Colloid and Interface Science, vol. 283, no. 2, pp. 344–351, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. M. G. Pérez-García, M. Rabelero, S. M. Nuño-Donlucas et al., “Semicontinuous heterophase polymerization of butyl methacrylate: effect of monomer feeding rate,” Journal of Macromolecular Science Part A. Pure and Applied Chemistry, vol. 49, no. 7, pp. 539–546, 2012. View at Publisher · View at Google Scholar
  25. M. G. Pérez-García, E. V. Torres, I. Ceja et al., “Semicontinuous heterophase copolymerization of styrene and acrylonitrile,” Journal of Polymer Science A: Polymer Chemistry, vol. 50, no. 16, pp. 3332–3339, 2012. View at Publisher · View at Google Scholar · View at Scopus
  26. M. G. Pérez-García, A. G. Alvarado, M. Rabelero et al., “Semicontinuous heterophase polymerization of methyl and hexyl methacrylates to produce latexes with high nanoparticles content,” Journal of Macromolecular Science A: Pure and Applied Chemistry, vol. 51, no. 2, pp. 144–155, 2014. View at Publisher · View at Google Scholar · View at Scopus
  27. M. G. Pérez García, A. G. Alvarado, L. A. Pérez-Carrillo et al., “On the modeling of the semicontinuous heterophase polymerization of alkyl methacrylates with different water solubilities,” Macromolecular Reaction Engineering, vol. 9, no. 2, pp. 114–124, 2015. View at Publisher · View at Google Scholar · View at Scopus
  28. H. Saade, C. Barrera, G. Guerrero, E. Mendizábal, J. E. Puig, and R. G. López, “Preparation and loaded with rifampicin of sub-50 nm poly(ethyl cyanoacrylate),” Journal of Nanomaterials, vol. 2016, Article ID 384973, 11 pages, 2016. View at Publisher · View at Google Scholar
  29. J. C. González-Iñiguez, V. M. Ovando-Medina, C. F. Jasso-Gastinel, D. A. González, J. E. Puig, and E. Mendizábal, “Synthesis of polypyrrole nanoparticles by batch and semicontinuous heterophase polymerizations,” Colloid and Polymer Science, vol. 292, no. 6, pp. 1269–1275, 2014. View at Publisher · View at Google Scholar · View at Scopus
  30. O. Esquivel, M. E. Treviño, H. Saade, J. E. Puig, E. Mendizábal, and R. G. López, “Mesoporous polystyrene nanoparticles synthesized by semicontinuous heterophase polymerization,” Polymer Bulletin, vol. 67, no. 2, pp. 217–226, 2011. View at Publisher · View at Google Scholar · View at Scopus
  31. J. E. Puig and M. Rabelero, “Semicontinuous microemulsion polymerization,” Current Opinion in Colloid and Interface Science, vol. 25, pp. 83–88, 2016. View at Publisher · View at Google Scholar · View at Scopus
  32. G. Singhvi and M. Sing, “Review: in-vitro drug release characterization models,” International Journal of Pharmaceutical Studies and Research, vol. 2, no. 1, pp. 77–84, 2011. View at Google Scholar
  33. G. Odian, Principles of Polymerization, Wiley Interscience, New York, NY, USA, 2004.