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Journal of Nanomaterials
Volume 2017, Article ID 7357150, 10 pages
https://doi.org/10.1155/2017/7357150
Research Article

Fabrication, Characterization, and In Vivo Evaluation of Famotidine Loaded Solid Lipid Nanoparticles for Boosting Oral Bioavailability

1Department of Pharmacy, University of Malakand, Chakdara, Dir (L), Khyber Pakhtunkhwa 18800, Pakistan
2Nano-Biotech Group, National Institute for Biotechnology and Genetic Engineering, Faisalabad 38000, Pakistan
3Ningbo Institute of Materials Technology and Engineering (NIMTE), Chinese Academy of Sciences (CAS), Ningbo, Zhejiang, China

Correspondence should be addressed to Mir Azam Khan; moc.oohay@687mazarim

Received 31 July 2017; Revised 14 November 2017; Accepted 20 November 2017; Published 14 December 2017

Academic Editor: Mohamed Bououdina

Copyright © 2017 Muhammad Shafique et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Famotidine as H2 receptor has antagonistic effects on gastric secretion. Unfortunately, its hydrophobic nature contributes to its variable and poor oral bioavailability. In the current study efforts are being made to fabricate famotidine loaded solid lipid nanoparticles with narrow size distribution. Prepared nanoformulations were pharmaceutically evaluated to confirm the desired boosted oral bioavailability. Famotidine loaded nanoformulation (FFSe-4) showed particle size  nm, polydispersity index , zeta potential − mV, entrapment efficiency %, and drug loading capacity %. Drug-excipients compatibility was confirmed by Fourier transformed infrared spectroscopy. Scanning electron microscopy confirmed spherical shaped, nanosized particles. Differential scanning calorimetry and powder X-ray diffractometry confirmed the change in crystalline nature. Prepared nanoformulation was more stable at refrigerated temperature. In vitro study showed that drug release time is proportional to drug pay load and followed zero order kinetics. Release exponent () confirmed non-Fickian-diffusion mechanism for drug release. In vivo pharmacokinetic studies showed 2.06-fold increase in oral bioavailability of famotidine dispersed in solid lipid nanoparticles compared to commercial product. These results authenticate solid lipid nanoparticles as drug delivery system and propose prolonged release with improved oral bioavailability for famotidine.