Star Polymer-Drug Conjugates with pH-Controlled Drug Release and Carrier Degradation

Table 2

Physicochemical characteristics of HMW copolymers and drug conjugate.

Star polymer	Polymer precursor	Dendrimer	Molar ratio polymer : dendrimer		Đ		Yield of star polymer (%)
S1	P2	, G3	11 : 1	280 000	1.74	15.2	82
S2	P2	, G4	19 : 1	450 000	1.71	17.5	69
S3	P3	, G3	12 : 1	280 000	1.27	11.7	97
	S3	, G3	—	320 000	1.38	12.3	—

Molecular weight was determined by SEC using RI and MALS detection.
Hydrodynamic radius was determined by DLS.
Star polymer-DOX conjugate containing 10.4 wt% DOX.