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Journal of Nanomaterials
Volume 2017 (2017), Article ID 9687896, 10 pages
https://doi.org/10.1155/2017/9687896
Research Article

Correlation between Structures and Antioxidant Activities of Polyvinylpyrrolidone/Garcinia mangostana L. Extract Composite Nanofiber Mats Prepared Using Electrospinning

1Department of Physics, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Bandung 40132, Indonesia
2Bioscience and Biotechnology Research Center, Institute for Research and Community Services, Institut Teknologi Bandung, Bandung 40132, Indonesia
3Pharmaceutics Research Division, School of Pharmacy, Institut Teknologi Bandung, Bandung 40132, Indonesia
4Nanoscience and Nanotechnology Research Center, Institute for Research and Community Services, Institut Teknologi Bandung, Bandung 40132, Indonesia

Correspondence should be addressed to Khairurrijal Khairurrijal

Received 31 March 2017; Accepted 1 June 2017; Published 18 July 2017

Academic Editor: Silvia Licoccia

Copyright © 2017 Ida Sriyanti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Nanofiber mats of polyvinyl(pyrrolidone) (PVP) with Garcinia mangostana extract (GME) as the encapsulated drug have been developed using electrospinning. SEM images of all electrospun PVP/GME composite nanofiber mats showed that they had similar and smooth morphology, no beads, and spindle shape. Its average diameter decreased and its surface area therefore increased with the decrease of its PVP concentration. The benefit of high surface area is obvious in drug delivery systems for poorly water-soluble drugs. Their FTIR spectra indicated that PVP and GME interacted intermolecularly via hydrogen bonds in the composite nanofiber mats. A conformational change in the C-H chain of PVP occurred in the composite nanofiber mats due to the intermolecular interactions. Their XRD patterns confirmed that they were amorphous because of amorphization during electrospinning. The XRD analyses also strengthened the FTIR studies; namely, GME and PVP formed intermolecular interactions in the electrospun composite nanofiber mats. As a result, GME as the encapsulated drug was molecularly dispersed in the electrospun PVP nanofiber matrix that functioned as a drug delivery system. From the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, the composite nanofiber mats exhibited very high antioxidant activities despite having been exposed to high voltage during electrospinning. Therefore, they are potential antioxidant products for food and pharmaceutics.