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Journal of Nanomaterials
Volume 2017 (2017), Article ID 9864396, 9 pages
https://doi.org/10.1155/2017/9864396
Research Article

Effect of Aluminum Incorporation into Mesoporous Aluminosilicate Framework on Drug Release Kinetics

1“Ilie Murgulescu” Institute of Physical Chemistry, Romanian Academy, 202 Splaiul Independentei, 060021 Bucharest, Romania
2Faculty of Applied Chemistry and Material Science, University “Politehnica” of Bucharest, 1-7 Polizu Street, 011061 Bucharest, Romania

Correspondence should be addressed to Cristian Matei; moc.oohay@ietam_itsirc

Received 6 March 2017; Revised 17 May 2017; Accepted 8 June 2017; Published 27 July 2017

Academic Editor: Miguel A. Correa-Duarte

Copyright © 2017 Raul-Augustin Mitran et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Mesoporous silica materials are promising nanocarriers for the development of drug delivery systems. In this study, the influence of pore size, volume, surface area, and doping the silica framework on the release kinetics of a model drug, metoprolol, has been studied. 20% or 50% wt. therapeutic agent was loaded into the carrier mesopores through incipient wetness impregnation. The carriers and drug-loaded samples have been characterized by small- and wide-angle X-ray diffraction, FT-IR spectroscopy, scanning electron microscopy, and nitrogen adsorption-desorption isotherms. The in vitro release profiles have been fitted using a three-parameter kinetic model and they have been explained in terms of the release rate during the burst and sustained release stages and the fraction of drug molecules released during the burst stage. The silica framework doping with aluminum was found to decrease the amount of drug released in the burst stage, without affecting the other kinetic parameters. The therapeutic agent release rates depend mainly on the pore size and volume of the mesoporous carriers and drug-loaded samples.