Journal of Nanomaterials / 2018 / Article / Tab 2

Research Article

Evaluation of Long-Term Inflammatory Responses after Implantation of a Novel Fully Bioabsorbable Scaffold Composed of Poly-L-lactic Acid and Amorphous Calcium Phosphate Nanoparticles

Table 2

The fibrin score is based on the following.

0No fibrin/fibrinoid deposits present
1Minimal, spotty, focal fibrin/fibrinoid deposits around the struts and/or throughout the neointima
2Mild to moderate fibrin/fibrinoid deposits around struts and/or throughout the neointima (small lakes locally bridging between two adjacent struts or widely distributed in coalescing flakes)
3Heavy fibrin/fibrinoid deposits around the struts, bridging between several adjacent struts and/or throughout the neointima

Fibrin (or fibrinoid deposits) is a normal and expected component of the neointima in the early stages of healing. In the process of organization, the neointima is primarily comprised of fibrin, and the amount decreases as organization progresses. Mature neointima usually contains no to very low levels of residual fibrin. Large amounts of residual fibrin can interfere with long-term stability of the neointima.