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Journal of Nanomaterials
Volume 2018 (2018), Article ID 1726438, 10 pages
https://doi.org/10.1155/2018/1726438
Research Article

Multifunctional Amine Mesoporous Silica Spheres Modified with Multiple Amine as Carriers for Drug Release

1Institute of Advanced Technology, Guizhou University, Guiyang 550025, China
2School of Chemistry and Chemical Engineering, Guizhou University, Guiyang 550025, China
3School of Electrical Engineering, Guizhou University, Guiyang 550025, China

Correspondence should be addressed to Qianlin Chen; nc.ude.uzg@nehclq

Received 27 April 2017; Accepted 18 July 2017; Published 8 January 2018

Academic Editor: Yan Zou

Copyright © 2018 Yan Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Mesoporous silica spheres were synthesized by using Stöber theory (MSN-40). Calcination of the mesostructured phase resulted in the starting solid. Organic modification with aminopropyl groups resulted in two MSN-40 materials: named MSN-NH2 and MSN-DQ-40, respectively. These two kinds of samples with different pore sizes (obtained from 3-[2-(2-aminoethylamino)ethylamino]propyl-trimethox-ysilane (NQ-62) and modified NQ-62) showed control of the delivery rate of ibuprofen (IBU) from the siliceous matrix. The obtained sample from modified NQ-62 has an increased loading rate and shows better control of the delivery rate of IBU than the obtained sample from NQ-62. These three solids were characterized using standard solid state procedures. During tests of in vitro drug release, an interesting phenomenon was observed: at high pH (pH 7.45), IBU in all carriers was released slowly; at low pH (pH 4.5), only a part of the IBU was slowly released from this carrier within 25 hours; most IBU was effectively confined in mesoporous material, but the remaining IBU was released rapidly and completely after 25 hours.