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Journal of Nanomaterials
Volume 2018, Article ID 2012140, 10 pages
https://doi.org/10.1155/2018/2012140
Research Article

Electrospun 4th-Generation Solid Dispersions of Poorly Water-Soluble Drug Utilizing Two Different Processes

1Department of Internal Medicine, The Hospital of Wuhan University of Science & Technology, Wuhan 430081, China
2School of Chemistry & Chemical Engineering, Wuhan University of Science & Technology, Wuhan 430081, China
3School of Materials Science & Engineering, University of Shanghai for Science & Technology, Shanghai 200093, China

Correspondence should be addressed to Wenbing Li; moc.621@gnibnewil and Deng-Guang Yu; nc.ude.tssu@710gdy

Received 2 October 2017; Accepted 16 January 2018; Published 26 February 2018

Academic Editor: Zeeshan Khatri

Copyright © 2018 Zhu Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Different from traditional solid dispersion (SD) for improving the dissolution rates of poorly water-soluble drugs, the upgraded 4th SD was developed to furnish a drug sustained-release profile. In this work, two different kinds of 4th SDs were fabricated using two electrospinning processes. One is a ternary SD (nanofibers F2) that consisted of ethyl cellulose (EC), polyethylene glycol 1000 (PEG), and tamoxifen citrate (TAM) from a modified coaxial process, and the other is a binary SD (nanofibers F1) which is comprised of EC and TAM from a single-fluid blending process. Scanning electronic microscopic observations demonstrated that F2 ( nm) showed a better quality than F1 ( nm) in terms of size and size distribution although both of them had a smooth surface morphology and a cross section. X-ray diffraction patterns verified that both SDs were amorphous nanocomposites owing to the favorable secondary interactions among these components, as suggested from the results of FTIR. In vitro dissolution experiments indicated that F2 could furnish an improved drug sustained-release characteristics compared to F1, exhausting all the contained TAM and having weaker leveling-off late release. The molecular behaviors of drug sustained-release from the binary 4th SD were suggested. The protocols reported here paved an alternative way for developing novel functional nanomaterials for effective delivery of poorly water-soluble drugs.