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Journal of Nanomaterials
Volume 2018 (2018), Article ID 2180518, 9 pages
Research Article

Semibath Polymerization Approach for One-Pot Synthesis of Temperature- and Glucose-Responsive Core-Shell Nanogel Particles

1King Abdullah Institute for Nanotechnology, King Saud University, Riyadh 11451, Saudi Arabia
2Central Metallurgical Research and Development Institute (CMRDI), Helwan, Cairo 11421, Egypt
3Department of Chemistry, King Saud University, Riyadh 11451, Saudi Arabia
4Department of Zoology, King Saud University, Riyadh 11451, Saudi Arabia

Correspondence should be addressed to Aslam Khan

Received 26 September 2017; Revised 23 December 2017; Accepted 14 January 2018; Published 8 February 2018

Academic Editor: Oscar Perales-Pérez

Copyright © 2018 Aslam Khan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Herein, we report a simple and easy procedure for the synthesis of core-shell structures of glucose-sensitive 3-acrylamidophenylboronic acid (APBA) and temperature-responsive P(NIPAm-AAc) shell nanogel particles using MBA as a cross-linker via free radical polymerization. The synthesized particles were approximately 100 nm and were cross-linked to one another. The shell thickness of the nanogel particles was adjusted by increasing the concentrations of NIPAm through the semibath approach during the process of polymerization. The synthesized colloidal nanogel particle shows thermoresponsive behaviors. The dynamic light scattering technique also confirmed the change in the size of particles dispersed in an aqueous solution upon increase/decrease in temperatures, which is the result of its volume phase transition temperatures (VPTT). The size and morphology of the particles were characterized by TEM, FE-SEM, and AFM. The sensitivity of these nanogel particles to temperature and glucose suggests that they have the potential for applications related to the delivery of self-regulated insulin.