Preparation and Drug Release Study of Novel Nanopharmaceuticals with Polysorbate 80 Surface Adsorption

Table 1

Particle size, polydispersity index (PDI), zeta potential, drug loading, and entrapment efficiency of CHP NPs at different feed ratios (1 : 2, 1 : 5, and 1 : 10).

Feed ratio	Particle size (nm)	PDI	Zeta potential (mV)	Drug loading (%)	Encapsulation efficiency (%)
1 : 2	273.3 ± 3.72	0.138 ± 0.013	−6.20 ± 0.40	12.02 ± 1.90	42.00 ± 5.65
1 : 5	260.7 ± 1.76	0.123 ± 0.004	−5.75 ± 0.64	13.42 ± 2.03	86.54 ± 1.31
1 : 10	266.8 ± 4.56	0.196 ± 0.019	−9.30 ± 0.39	7.40 ± 1.72	59.71 ± 4.43