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Journal of Nanomaterials
Volume 2018, Article ID 4857461, 12 pages
Review Article

Hot Topics and Challenges of Regenerative Nanoceria in Application of Antioxidant Therapy

1College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, China
2Inner Mongolia Key Lab of Nanoscience and Nanotechnology, Inner Mongolia University, Hohhot 010021, China

Correspondence should be addressed to Jun Zhang; nc.ude.umi@gnahzjec

Received 17 April 2017; Accepted 20 November 2017; Published 24 January 2018

Academic Editor: Kimberly Hamad-Schifferli

Copyright © 2018 Changyan Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


As a new antioxidant, nanoceria is of significant importance in applications of medical and biological fields. In comparison with conventional organic antioxidants, nanoceria has multienzyme mimetic activity by redox cycle. This unique regenerative/autocatalytic property has been widely used in the aspects of free-radical scavenger, radiation protection, oxidative-stress-related disease, drug delivery, biosensor, tissue engineering, cancer biomarker, and anti-inflammatory. This paper reviews the latest breakthrough of nanoceria as an antioxidant in applications of medical and biological fields on the base of the authors’ research works on resistance to oxidation and cytotoxicity. The challenges of nanoceria encountered in applications in medical and biological fields are commented as well.