Polymer-Stabilized Micelles Reduce the Drug Rapid Clearance In Vivo

Table 2

Pharmacokinetic parameters of P-MCL, MCL, and free CL.

	Unit	P-MCL	MCL	Free CL
Dosage	mg/kg	22	22	22
	h	2.04 ± 0.27	1.91 ± 0.27	1.87 ± 0.26
AUC	h·μg/mL	24.41 ± 1.51	13.92 ± 2.09	9.66 ± 3.21
Clearance	L/h/kg	0.88 ± 0.05	1.57 ± 0.27	2.37 ± 0.65
MRT	h	1.04 ± 0.14	0.94 ± 0.07	0.92 ± 0.12
	L/kg	2.60 ± 0.46	4.28 ± 0.39	6.54 ± 2.51