Exosomes: A Paradigm in Drug Development against Cancer and Infectious Diseases

<table class="fixed-width table-group" id="tab5"><tr><td><table class="table"><colgroup><col style="width:16.88em"/><col style="width:14.65em"/><col style="width:19.11em"/><col style="width:14.65em"/></colgroup><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td class="align_left">Mechanism of exosomal removal</td><td class="align_center">Disease</td><td class="align_center">Effect</td><td class="align_center">Ref.</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td class="align_left">Extracorporeal hemofiltration of exosomes</td><td class="align_center">Hepatitis C</td><td class="align_center">Minimize viral titers in patients</td><td class="align_center">[<a href="/journals/jnm/2018/6895464/#B147" target="_blank">39</a>]</td></tr><tr><td class="align_left" colspan="4"><hr/></td></tr><tr><td class="align_left">Exosome enervation by Dimethyl amiloride (DMA) in mice</td><td class="align_center">Colorectal cancer</td><td class="align_center">Restore the cyclophosphamide (CTX) anti-tumor effect through the inhibition of MDSC functions</td><td class="align_center"> [<a href="/journals/jnm/2018/6895464/#B148" target="_blank">40</a>]</td></tr><tr><td class="align_left" colspan="4"><hr/></td></tr><tr><td class="align_left">Extracorporeal filtration of exosomes (The Hemopurifier)</td><td class="align_center">Advanced stage of cancer patients</td><td class="align_center">To remove exosomes from the blood</td><td class="align_center"> [<a href="/journals/jnm/2018/6895464/#B149" target="_blank">41</a>]</td></tr><tr><td class="align_left" colspan="4"><hr/></td></tr><tr><td class="align_left">Adjunct therapeutic method HER2osome</td><td class="align_center">Breast cancer</td><td class="align_center">Decrease the tumor secreted HER2 containing exosomes in circulation and afterward impede HER2 positive breast cancer progression</td><td class="align_center">[<a href="/journals/jnm/2018/6895464/#B31" target="_blank">42</a>]</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Novel strategies/devices of exosomal removal for cancer and infectious disease therapy.</div>

Journal of Nanomaterials

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Table 5

Table 5: Exosomes: A Paradigm in Drug Development against Cancer and Infectious Diseases 