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Journal of Nanomaterials
Volume 2018, Article ID 8540172, 9 pages
Research Article

Synthesis of Gold Nanoparticles to Capture Lifelike Proteins: Application on the Multichannel Sensor Array Design

1College of Physics and Electronic Engineering, Nanyang Normal University, Nanyang 473061, China
2College of Mechanical and Electronic Engineering, Nanyang Normal University, Nanyang 473061, China
3College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, China

Correspondence should be addressed to Yumin Leng; moc.621@gnel_nimuy

Received 1 August 2017; Revised 26 November 2017; Accepted 5 December 2017; Published 9 January 2018

Academic Editor: Naiqian Zhan

Copyright © 2018 Yumin Leng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The chemical elements of proteins are similar to that of DNA (e.g., C, H, O, and N), and DNA shows different knotted architectures. So we imagine that proteins may show a wealth of highly complex structures, especially when proteins interact with each other. The imagination was proved by synthesizing gold nanoparticles (GNPs) to capture the lifelike protein structures. The optical responses (i.e., color) of as-prepared GNPs are found to be characteristic to a given protein (or heavy metal ion). Based on the “three colors” principle of Thomas Young, we extracted the red, green, and blue (RGB) alterations of as-synthesized GNPs to fabricate multichannel sensor arrays for proteins (or heavy metal ions) discrimination. The designed multichannel sensor arrays demonstrate possibilities in semiquantitative analysis of multiple analytes (e.g., proteins and heavy metal ions). This work is believed to open new opportunities for GNPs-based label-free sensing.