Polymeric Nanogels as Versatile Nanoplatforms for Biomedical Applications

Table 4

NGs for ophthalmic delivery.

NG composition	Type of NG	Drug/agent used	Method of preparation	Results and applications	References
Nanodiamond, chitosan, poly(hydroxy ethyl methacrylate) matrix	Diamond NG	Timolol maleate	Spontaneous cluster formation	Lysozyme mediated sustained release; Enhanced retention in the eye; Localized delivery to treat glaucoma	[139]
Polyvinylpyrrolidone and acrylic acid (AAc)	NG	Pilocarpine	γ radiation-induced; Polymerization	Sustained drug release and improved bioavailability response	[140]
PLGA, chitosan	In situ NG	Levofloxacin		Sustained drug release; Enhanced corneal retention; Slow drug clearance	[141]
Chitin	NG	Fluconazole	Controlled regeneration chemistry method	Good penetration to the cornea; Effective for the treatment of corneal fungal infection	[142]
Cyclodextrin	NG	Dexamethasone	Emulsion-solvent; Evaporation	Controlled drug release by adhering to the ocular surface.; Enhanced ocular bioavailability.; Extended drug retention at eye surface	[143]
PLA, sodium alginate	In situ NG	5-Fluorouracil	Emulsion-solvent; Evaporation	Controlled drug release; Enhanced retention of gel; Effective ophthalmic delivery system for the treatment of conjunctival/corneal squamous cell carcinoma (CCSC)	[144]
N-Isopropyl acrylamide, 2-hydroxy-methacrylate; Lactide–dextran		Tacrolimus		Sustained drug release profile; Increased penetration to the cornea	[98]