Lipid Nano- and Microparticles: An Overview of Patent-Related Research

Table 2

Most important patents that concern the preparation methods for lipid nano- and microparticles.

Preparation method	Patent number	Lipid particle type	Size range	Ref.
HPH	WO0103670	SLN, NLC, and LDC	50-1000 nm	[44]
	WO2015148483			[45]
Solvent evaporation	WO2008013785	SLN	<240 nm	[46]
Solvent displacement	WO2011127255	SLN	<150 nm	[47]
	CN201010112202	SLN, NLC		[48]
Microemulsion templates	US5250236	SLN	50-300 nm	[49]
	US7153525			[50]
	IN127/DEL/2012			[51]
Coacervation	WO2008149215	SLN	200-1000 nm	[52]
SFEE	WO2004004862	SLN	20-90 nm	[29]
GAMA	WO2007028421	SLN, SLM	0.2-20 μm	[30]
Microwave assisted	WO2018109690	SLN, NLC	60-300 nm	[53]
DAC	EP1838286	SLN	15-200 nm	[54]
Membrane contactor	WO2007000531	SLN	100-200 nm	[35]
Temperature phase inversion	WO2009004214	LNC	30-100 nm	[55]
	WO2011036234			[56]
Melt dispersion	US2010233344	SLM	1-250 μm	[57]
	WO2010075065			[58]
Cryogenic micronization	US2004091522	SLM	1-500 μm	[59]
Spray-drying	WO2006066367	SLN, SLM	0.3-10 μm	[60]
	WO0185137			[61]
Electrospray	ITTO2008A000475	SLN, SLM	Nearly 1 μm	[62]
Spray-congealing	WO9603979	SLM	50-2000 μm	[63]