Review Article
Lipid Nano- and Microparticles: An Overview of Patent-Related Research
Table 2
Most important patents that concern the preparation methods for lipid nano- and microparticles.
| Preparation method | Patent number | Lipid particle type | Size range | Ref. |
| HPH | WO0103670 | SLN, NLC, and LDC | 50-1000 nm | [44] | WO2015148483 | [45] | Solvent evaporation | WO2008013785 | SLN | <240 nm | [46] | Solvent displacement | WO2011127255 | SLN | <150 nm | [47] | CN201010112202 | SLN, NLC | [48] | Microemulsion templates | US5250236 | SLN | 50-300 nm | [49] | US7153525 | [50] | IN127/DEL/2012 | [51] | Coacervation | WO2008149215 | SLN | 200-1000 nm | [52] | SFEE | WO2004004862 | SLN | 20-90 nm | [29] | GAMA | WO2007028421 | SLN, SLM | 0.2-20 μm | [30] | Microwave assisted | WO2018109690 | SLN, NLC | 60-300 nm | [53] | DAC | EP1838286 | SLN | 15-200 nm | [54] | Membrane contactor | WO2007000531 | SLN | 100-200 nm | [35] | Temperature phase inversion | WO2009004214 | LNC | 30-100 nm | [55] | WO2011036234 | [56] | Melt dispersion | US2010233344 | SLM | 1-250 μm | [57] | WO2010075065 | [58] | Cryogenic micronization | US2004091522 | SLM | 1-500 μm | [59] | Spray-drying | WO2006066367 | SLN, SLM | 0.3-10 μm | [60] | WO0185137 | [61] | Electrospray | ITTO2008A000475 | SLN, SLM | Nearly 1 μm | [62] | Spray-congealing | WO9603979 | SLM | 50-2000 μm | [63] |
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