Lipid Nano- and Microparticles: An Overview of Patent-Related Research

Table 3

Most important patents concerning the use of lipid nano- and microparticles for specific administration routes.

Administration route	Patent number	Lipid particle type	Aim	Ref.
Dermal	WO2010051918	SLN, SLM	Codelivery of metal nanoparticles and SLN/SLM in dermal formulations	[70]
	WO2010112749	SLN	Dermal composition for minoxidil delivery	[71]
	WO0103652	SLN	Increase in UV filter efficacy and stability through nanoparticulate delivery	[72]
	WO2008041116	SLN	Transdermal delivery of drugs with short half-lives and/or high activity	[73]
	WO2004098555	SLN	Targeted release of fragrances and aromas	[74]
	US20100104522	NLC	Skin delivery of omega-3 fatty acid for antiaging and moisturizing purposes	[75]
	WO2009111852	SLN	Formulation of retinoids in the form of ion pairs with lipophilic amines, suitable for skin delivery	[76]
	US20130034612	LNC	Avermectin delivery for acne rosacea treatment	[77]
	WO2014077712	SLN	Roxithromycin topical delivery to stop hair loss or for acne treatment	[78]
	WO2017143421	SLN	Cosmetic composition aimed at the sustained release of substances that repel insects	[79]
	BR1020140173161	SLN	A method to obtain trans-resveratrol- (RES-) loaded SLN and their use in the antitumor therapy of melanoma	[80]
	IN611/MUM/2011	SLN	Terbinafine-loaded SLN incorporated into a gel with enhanced skin deposition and improved antifungal activity	[81]
	IN149/CHE/2014	SLN	Improved treatment of psoriasis	[82]
	IN3658/MUM/2014	SLN	Mupirocin SLN incorporated into a Carbopol-based gel to enhance efficacy in skin infection treatment	[83]
	IN201711046022	SLN	SLN used as a carrier in the development of transdermal patches for diltiazem permeation	[84]
	IN428/DEL/2010	SLN	Topical antioxidants loaded in SLN as therapeutics to combat photoageing	[85]
	IN1394/DEL/2011	SLN	Gel loaded with vitamin D analogues and corticosteroids entrapped in SLN to treat psoriasis	[86]
	IN26/KOL/2014	SLN	Acyclovir-loaded SLN to avoid systemic drug penetration through the skin	[87]
	WO2012127037	NLC	Vitamin D and corticosteroid coloaded into NLC in order to increase drug accumulation in the skin	[88]
Parenteral	WO2009102121	SLN	Cacao butter nanoparticles that are suitable for the parenteral administration of drugs	[89]
Oral	US2011082214	SLN	Preparation of tablets from SLN suspensions	[90]
	EA200900215	SLN	Treatment of tuberculosis and diseases mediated by Helicobacter pylori via the peroral administration of SLN loaded with rifabutin and rifampicin	[91]
	WO2014140268	SLN	Delivery of food grade actives in SLN (antimicrobial, antioxidants, polyphenols, vitamins, etc.)	[92, 93]
	CN201510071840	SLN	Increase in docetaxel oral bioavailability via the use of freeze-dried quaternary ammonium salt chitosan-modified SLN	[94]
	KR20150093510	SLN	Formulation of docetaxel in SLN for oral delivery	[95]
	WO2015039199	SLN, LNC, and nanoemulsions	Improvement of the dissolution profile of benznidazole with increased bioavailability	[96]
	CN200910192553	SLN	Increase in the oral uptake of lappaconitine-loaded SLN, prepared using HPH	[97]
	CN200910034968	SLN	Increase in Tripterygium glycoside dissolvability, improving oral bioavailability	[98]
	CN200910027782	SLN	Solving the problems of the low solubility, low dissolution rate, and low bioavailability of finasteride	[99]
	CN201410531574	SLN	Increased bioavailability of asiatic acid	[100]
	CN201010224865	NLC	Agglutinin-modified and glutaraldehyde cross-linked NLC for the oral delivery of insoluble compounds	[101]
	IN430/DEL/2004	SLN	Antitubercular drug (rifampicin, isoniazid, and pyrazinamide) association for oral delivery	[102]
	IN3139/DEL/2005	SLN	Improved bioavailability of drugs via gut lymphatic system absorption	[103]
	IN3310/DEL/2012	SLN	Cocoa-butter SLN loaded with tenofovir with controlled release	[104]
	IN3356/DEL/2012	SLN	Improved bioavailability of rifampicin and limited drug degradation and interaction with isoniazid in the acidic environment of the stomach	[105]
	IN3509/DEL/2012	SLN	Azathioprine-loaded SLN with prolonged release with the aim of colon delivery	[106]
	IN264/DEL/2013	SLN	Lercanidipine enhanced oral bioavailability and prolonged release of action	[107]
	IN1365/MUM/2014	SLN	Sustained release of glipizide	[108]
	IN3329/MUM/2010	SLN	Treatment of fungal infections and leishmaniasis with amphotericin B-loaded SLN	[109]
	IN2194/CHE/2010	SLN	Improved oral bioavailability of olanzapine	[110]
	IN2960/DEL/2014	SLN	SLN loaded with the extract of the aerial portion of Ficus benjamina are incorporated into floating tablets	[111]
Pulmonary	WO2009050217	SLM	Spray-dried powder for dry inhalers with enhanced flow and dispersal properties	[112]
Ocular	WO2004039351	SLN	Suitable eye-drop composition for the treatment of ocular diseases	[113]
	WO2012085318	SLN	Treatment of ocular diseases using nucleic acid-complexed SLN	[114]
	WO2016055976	SLN, NLC	Silibinin-loaded mucoadhesive SLN, NLC, and calixarenes, with sustained drug release, for the treatment of ocular neurodegenerative diseases	[115]
	IN2339/DEL/2014	SLN	Statin-loaded SLN for topical application and the treatment of age-related macular degeneration, glaucoma, and other ocular inflammatory diseases	[116]
	CN201610005904	NLC	NLC - intraocular lens system, which is loaded with anti-inflammatory drugs and antibiotics, in order to prevent or treat cataract surgery complications	[117]