Lipid Nano- and Microparticles: An Overview of Patent-Related Research

Table 5

Most important marketed and close-to-market products that contain lipid nano- and microparticles.

Manufacturer	Trademark	Lipid particles type	Drug/active	Administration route	Field of application	Reached development stage	Ref.
Alpha RX	Ocusolin	SLN	Gentamicin	Ocular	Pharma	Preclinical	[183]
	Zysolin	SLN	Tobramicin	Pulmonary, parenteral	Pharma	Preclinical	[183]
	Vansolin	SLN	Vancomicin	Parenteral	Pharma	Preclinical	[183, 184]
AmorePacific	IOPE Line	NLC	Ubidecarenone, omega-3 and omega-6 unsaturated fatty acids	Dermal	Cosmetic	Marketed	[124]
Bayer HealthCare Pharmaceuticals Inc.	Cipro	SLN	Ciprofloxacin	Oral	Pharma	Marketed	[185, 186]
Beate Johnen	NLC deep effect eye serum	NLC	Ubidecarenone, highly active oligosaccharides	Dermal	Cosmetic	Marketed	[124]
	NLC deep effect repair cream	NLC	Ubidecarenone, TiO2, and highly active oligosaccharides	Dermal	Cosmetic	Marketed	[124]
	NLC deep effect reconstruction cream	NLC	Ubidecarenone, acetyl hexapetide-8, highly active oligosaccharides in polysaccharide matrix, and micronized plant collagen	Dermal	Cosmetic	Marketed	[124]
Boehringer	Mucosolvan Retard	SLN	Ambroxol	Oral	Pharma	Marketed	[184]
Chemisches Laboratorium (Dr. Richter)	NanoLipid Restore CLR	NLC	Black currant seed oil	Dermal	Cosmetic	Marketed	[124, 183]
	NanoLipid Q10 CLR	NLC	Ubidecarenone and black currant seed oil	Dermal	Cosmetic	Marketed	[124]
	NanoLipid Basic CLR	NLC	—	Dermal	Cosmetic	Marketed	[124]
	NanoLipid Repair CLR	NLC	Black currant seed oil and manuka oil	Dermal	Cosmetic	Marketed	[124]
Dr. Rimpler	Cutanova Cream Nanorepair Q10	NLC	Ubidecarenone, polypeptide, Hibiscus extract, ginger extract, and ketosugar	Dermal	Cosmetic	Marketed	[124]
	Intensive Serum Nanorepair Q10	NLC	Ubidecarenone, polypeptide, Acmella oleracea extract	Dermal	Cosmetic	Marketed	[124]
	Cutanova Cream Nanovital Q10	NLC	Ubidecarenone, TiO2, polypeptide, ursolic acid, oleanolic acid, and sunflower seed extract	Dermal	Cosmetic	Marketed	[124]
Dr. Theiss	Olivenöl Anti Falten Pflegekonzentrat	NLC	Olea europaea oil, panthenol, Acacia senegal, tocopheryl acetate	Dermal	Cosmetic	Marketed	[124]
	Olivenöl Augenpflegebalsam	NLC	Olea europaea oil, Prunus amygdalus Dulcis oil, hydrolyzed milk protein, tocopheryl acetate, Rhodiola rosea root extract, and caffeine	Dermal	Cosmetic	Marketed	[124]
Isabelle Lancray	Surmer Crème Legère Nano-Protection	NLC	Kukui nut oil, Monoi Tiare Tahiti®, pseudopeptide, coconut milk, and wild indigo	Dermal	Cosmetic	Marketed	[124]
	Surmer Crème Riche Nano-Restructurante	NLC	Kukui nut oil, Monoi Tiare Tahiti®, pseudopeptide, coconut milk, wild indigo, and tamanol	Dermal	Cosmetic	Marketed	[124]
	Surmer Elixir du Beauté Nano-Vitalisant	NLC	Kukui nut oil, Monoi Tiare Tahiti®, pseudopeptide, coconut milk, and wild indigo	Dermal	Cosmetic	Marketed	[124]
	Surmer Masque Crème Nano-Hydratant	NLC	Kukui nut oil, Monoi Tiare Tahiti®, pseudopeptide, coconut milk, wild indigo, and tamanol	Dermal	Cosmetic	Marketed	[124]
	Surmer Crème Contour Des Yeux Nano-Remodelante	NLC	Kukui nut oil, pseudopeptide, hydrolyzed wheat protein, Ximenia americana seed oil, and tamanol	Dermal	Cosmetic	Marketed	[124]
Kemin Industries	FloraGlo	NLC	Lutein	Oral	Food	Marketed	[187]
La Prairie	Swiss Cellular White	NLC	Glycoproteins, Panax ginseng root extract, Equisetum arvense extract, Camellia sinensis leaf extract, and Viola tricolor extract	Dermal	Cosmetic	Marketed	[124]
Pharmasol	TransoPlex	Cationic SLN	—	Parenteral	Pharma	Preclinical	[183]
Pharmatec (Sigmoid Pharma)	CyCol	SLN	Cyclosporine	Oral	Pharma	Preclinical	[183, 188]
Scholl	Regenerations Creme Intensiv	NLC	Macadamia ternifolia seed oil, avocado oil, urea, and blackcurrant seed oil	Dermal	Cosmetic	Marketed	[124]
Yamanouchi	Nanobase	SLN	—	Dermal	Cosmetic	Marketed	[183]