Precise Control of Gold Nanoparticles on DNA Origami for Logic Operation

Figure 1

(a) Scheme of YES gate. (b) Gel electrophoresis analysis. Lane 1: AuNP without DNA modification. Lane 2: AuNP modified with A-SH. Lane 3: AuNP modified with B-SH. Lane 4: M13. Lane 5: TL origami. Lane 6: TL origami mixed with Au-A (TL-A). Lane 7: sample after adding A to lane 6. Lane 8: TL origami mixed with Au-B (TL-B). Lane 9: sample after adding B to lane 8. (c, d) TEM images of Au-B-bound TL (TL-B) and Au-B-released TL. (e) Distribution histograms of YES gate A: blue bars indicate TL-A and gray bars indicate TL; solid lines represent curve fitting. (f) Distribution histograms of YES gate B: green bars indicate TL-B and gray bars indicate TL; solid lines represent curve fitting.

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