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Journal of Nanomaterials
Volume 2019, Article ID 5384132, 13 pages
https://doi.org/10.1155/2019/5384132
Research Article

Highly Crystalline WO3 Nanoparticles Are Nontoxic to Stem Cells and Cancer Cells

1Jiangsu University of Technology, Changzhou 213001, China
2Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino 142290, Russia
3Lomonosov Moscow State University, Moscow 119991, Russia
4Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences, Moscow 119991, Russia
5Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Kyiv D0368, Ukraine
6National Research Tomsk State University, Tomsk 634050, Russia

Correspondence should be addressed to V. K. Ivanov; ur.sar.cigi@nav

Received 26 September 2018; Accepted 10 February 2019; Published 28 April 2019

Academic Editor: Elisabetta Comini

Copyright © 2019 B. Han et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Tungsten oxide sol, containing highly crystalline nanoparticles of orthorhombic WO3 and having good sedimentation stability, was synthesized using a facile, ultrasonic-assisted technique. An additional steric stabilizer, dextran, was proposed to enhance the stability of WO3 nanoparticles in biological media and to reduce their in vivo toxicity. The cytotoxicity of dextran-stabilized and nonstabilized WO3 sols was studied in vitro using dental pulp stem (DPS) cell lines and breast cancer (MCF-7) cell lines. Both tungsten oxide sols demonstrated low cytotoxicity and low genotoxicity for both stem cells and malignant cells and only slightly reduced their metabolic activity in the concentration range studied (from 0.2 to 200 μg/ml). The data obtained support possible theranostic applications of tungsten oxide colloidal solutions.