Size-Dependent Cytotoxicity and Genotoxicity of Silver Nanoparticles in Cochlear Cells In Vitro

Figure 4

TEM images of control cells from the two cell lines. (a) Control HaCaT cell with a normal ultrastructure showing a large indented nucleus (n) with a prominent nucleolus (nu), many cell organelles and glycogen granules (g) in the cytoplasm, and a high number of extensions of the plasma membrane (pm). (b) Normal ultrastructure of a cell of the HEI-OC1 line with a large oval nucleus (n) with nucleolus (nu), few profiles of rough endoplasmic reticulum (rer) in the cytoplasm, and a low number of extracellular extensions of the plasma membrane (pm).

(a)

(b)