Hydroxyapatite Nanoparticle Coating on Polymer for Constructing Effective Biointeractive Interfaces

Figure 11

Possible schemes of the protein interactions with the hydration layer on the HAp surface during protein adsorption. (a) In the beginning, hydrated fibrinogen (Fgn) interacts with the hydration layer with possible dehydration. Then, Fgn absorbs on HAp. Finally, conformational change from “side-on,” at initial adsorption region, to “end-on” at the saturated adsorption region. (b) The adsorption model of albumin (Ab) could be “side-on” at the initial adsorption region and also at the monolayer. Nonfreezing water could suppress the denaturalization of the adsorbed proteins suggesting fusion interfaces. Reprinted with permission from [246], S. Yamada et al. Mater. Lett., 209, 441—445, (2017) © 2017, Elsevier. [247], M. Tagaya et al. Mater. Express, 2, 1—22, (2012) © 2012, American Scientific Publishers,

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