Effect of Size, Shape, and Composition on the Interaction of Different Nanomaterials with HeLa Cells

Figure 7

Interaction of ZnO nanoparticles and nanowires with HeLa cells. (a) Graphic illustration of the intracellular cycle of ZnO nanomaterials in HeLa cells. (b) TEM characterization of ZnO nanoparticles (A) and nanowires (B). (c) Phase contrast images of HeLa cells exposed to 50 μg/ml of ZnO nanoparticles (A) and nanowires (B) during 72 h. (d) Confocal microscopy images demonstrating the cytotoxic effects of ZnO nanoparticles (A) and nanowires (B) of HeLa cells. Cytoskeletal abnormalities are clearly visible. (e) HeLa cell viability after ZnO nanoparticle exposure.

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