Characterization and Evaluation of HGF-Loaded PLGA Nanoparticles in a CCl₄-Induced Acute Liver Injury Mouse Model

Figure 6

The mechanism of HGF-loaded PLGA nanoparticles on acute liver injury induced by CCl₄ in experimental mice. A single dose of CCl₄ can cause acute liver injury in mice. SOD and GPX are consumed, and MDA is produced and released into blood. In addition, liver enzymes, such as AST, ALT, ALP, and T-BIL, are released into the blood. HGF-loaded nanoparticles may release HGF slowly and maintain HGF at a high concentration. HGF may protect hepatocytes, enhance the antidamage ability of hepatocytes, and protect the vitality of hepatocytes.