Research Article

Interaction of Mitoxantrone-Loaded Cholesterol Modified Pullulan Nanoparticles with Human Serum Albumin and Effect on Drug Release

Table 1

Degree of coverage, affinity (binding constant, ), and enthalpy and entropy changes for binding with HSA titrated into the following sample solutions.

SampleCoverage (104 M-1) (kJ/mol)ΔS° (kJ/mol·K)

MTO
CHP
MTO-CHP






0.089
0.251
1.634

Data are .