Simvastatin-Loaded Nanomicelles Enhance the Osteogenic Effect of Simvastatin

Figure 1

The surgical procedures with rabbit calvaria. (a) A mucoperiosteal flap was raised, and four critical bone defects (6.5 mm in diameter) were created at the top of the skull. (b) The defects were divided into the following four groups: no augmentation (blank control, BC) group, gelatin sponge (GS) group, gelatin sponge with 0.5 mg SV (SV-GS) group, and gelatin sponge with 5 mg SVNs (0.5 mg SV) (SVNs-GS) group.