Review Article
3D Nanostructures for Tissue Engineering, Cancer Therapy, and Gene Delivery
Table 1
GO-based nanoparticle application in the engineering of bone tissue.
| Method of NP synthesis | Cell type | Mechanical strength (MPa) | Application | Ref. |
| Modified Hummers’ method | mMSCs | 53 | In vivo | [48] | Modified “Hummers’ and Offeman’s” method | Osteogenesis of MC3T3-E1 preosteoblasts | — | In vivo | [49] | Modified Hummers’ method | MC3T3 cells | 10.0 | In vitro | [50] | Modified Hummers’ method | Rat mesenchymal stem cell line | | In vivo and in vitro | [51] | Modified Hummers’ method | Mesenchymal stem cells | | N/A | [51] | Electrostatic LBL assembly followed by electrochemical deposition | MC3T3-E1 osteoblast | | N/A | [52] | Prepared by chemical oxidation of graphite flakes following a modified Hummers’ process | Human osteoblast cell line Saos-2 | | N/A | [53] | Modified Hummers’ and Offeman’s method | Osteoblastic MC3T3 E1 cell | 0.125 | In vitro and in vivo | [53] | Modified Hummers’ method | Human periodontal ligament stem cells | — | In vitro | [54] | Biomineralization of GO/C scaffolds | Bone marrow stromal cells | 0.65 | In vivo and in vitro | [55] |
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