A Unique Protein Self-Assembling Nanoparticle with Significant Advantages in Vaccine Development and Production

Figure 1

Structure of the NSP10 dodecamer NSP10 dodecahedron as viewed down one of the threefold axes showing the close association of the three N-terminal helices of subdomain I. Each monomeric protein, twelve in total, is shown in a different color. An important consequence of the NSP10 particle point symmetry (point group 32) is that each N-terminal threefold set has a corresponding C-terminal set which is collinear on the same 3-fold axis, but located on the directly opposite capsid surface. The depicted NSP10 oligomer represents residues 9 to 129. The illustration was created using coordinates from the Protein Data Bank (PDB): 2G9T [9] and the program Chimera.