A Unique Protein Self-Assembling Nanoparticle with Significant Advantages in Vaccine Development and Production

Figure 3

Hypothetical graphical models of NSP10 fusion proteins. (a) Atomic model illustration depicting NSP10 with a hemagglutinin stem fusion at the N-termini. Note the tetrahedral arrangement provides nonsterically hindered access to the stalk domains. The C-termini are shown as red patches on the capsid surface and provide for the potential of additional protein fusions or affinity tags. (b) Atomic model of a hypothetical NSP10 dual stem display incorporating a hemagglutinin at the N-terminus and a Sigma C reovirus stem at the C-terminus.

(a)

(b)