The Synthesis of Glutamine-Functionalized Block Polymer and Its Application in Triple-Negative Breast Cancer Treatment
Antitumor efficacy of Gln-PEG-b-PAE@DOX in vivo. (a) Schematic illustration of the in vivo experiment. (b) Tumor growth curves of tumor-bearing mice treated with saline, DOX, mPEG-b-PAE@DOX, and Gln-PEG-b-PAE@DOX. (c, g) Fluorescence photo and total flux of mice treated with saline (1), DOX (2), mPEG-b-PAE@DOX (3), and Gln-PEG-b-PAE@DOX (4). (d) Photographs of dissected tumors of the control group (1), free DOX group (2), mPEG-b-PAE@DOX group (3), and Gln-PEG-b-PAE@DOX group (4). (e, f) Volume and weight of dissected tumors. Comparisons between the groups were performed using one-way analysis of variance (ANOVA); ,,, and .