Antimicrobial Activity of Isoniazid in Conjugation with Surface-Modified Magnetic Nanoparticles against Mycobacterium tuberculosis and Nonmycobacterial Microorganisms

Table 1

Antibacterial activity of nanoconjugated compounds against nonmycobacterial bacteria in comparison with pure INH.

	INH		INH@MNP		INH@smMNP
	MIC50	MIC90^††	MIC50	MIC90	MIC50	MIC90
E. faecalis	125	>500	2	>32	1.187	9.5
S. aureus^†	>500	>500	16	>32	9.5	38
E. coli^‡	500	>500	16	>32	9.5	38
P. aeruginosa^§	>500	>500	16	>32	9.5	38

E. faecalis = Enterococcus faecalis. ^†S. aureus = Staphylococcus aureus. ^‡E. coli = Escherichia coli. ^§P. aeruginosa = Pseudomonas aeruginosa. MIC50 represents the minimum required concentration (μg/mL) of an antibacterial agent to inhibit at least 50% of bacterial growth. ^††MIC90 represents the minimum required concentration (μg/mL) of an antibacterial agent to inhibit at least 90% of bacterial growth.