A Novel Label-Free Biosensor for Detection of HE4 in Urine Based on Localized Surface Plasmon Resonance and Protein G Directional Fixed

Table 4

HE4 detection in urine of different study groups with CLIA method (based on Chemiluminescence Immunoassay method [14]).

Study groups	Testing HE4 in urine (concentration)					±SD; (n =5, pmol/L)
	Case 1	Case 2	Case 3	Case 4	Cases 5
Healthy women	0.38	0.45	0.33	0.41	0.36	0.39 ± 0.05
Benign ovarian cyst patients	0.59	0.48	0.62	0.47	0.51	0.53 ± 0.07
Early ovarian cancer patients	2.01	2.79	1.96	2.82	2.33	2.38 ± 0.41