Synthesis and Application of Iron Oxide Nanoparticles in Bone Tissue Repair

Figure 3

Synthesis in vitro and physicochemical properties in rabbit cartilage of CNC/Dex/USPIO-KGN. (a) Schematic illustration of preparation and utilization of USPIO-labeled Dex/CNC/USPIO-KGN hydrogels for engineering artificial cartilage repair. (b) Reduced modulus and hardness (reduced modulo is a “combined” modulus of the tip and the sample and can be directly evaluated from analysis of stress-strain data according to specific equations). (c) Observations of cartilage harvested; MRI and H&E during 6 weeks and 12 weeks. H&E staining shows that the neocartilage integrated with the adjacent normal cartilage. Reproduced with permission from [127].