Synthesis and Application of Iron Oxide Nanoparticles in Bone Tissue Repair

Table 1

Synthesis method of IONPs.

Method	Advantage	Disadvantage	Reference
Organic based	High particle dispersion	Unruly IONPs’ appearance	[40–42]
Hydrothermal/solvothermal	Simple operation; High reaction efficiency; Suitable for wider temperature range	Hard to replicate metastable phase and nanomorphology in other ways	[43–47]
Coprecipitation	Simple operation; High-yield	Poor controllability of its particle size and distribution	[48–51]
Ball milling	Granularity reproducibility	IONP aggregation; Expensive; Long cycle; Hard to realize industrial production	[52–55]
Sol-gel	Small particle size; Good dispersion	Expensive; Long duration; Easy to shrink during drying	[56–60]
Atomic layer deposition	Accurate thickness control; Good uniformity	Slow deposition rate	[61–63]