Nanoparticle-Based Drug Delivery System—A Target Strategy for Osteoarthritis Treatment

Table 3

Classification and characteristics of nanoparticle-based drug delivery system.

Nanocarriers	Classification	Advantage	Disadvantage
Lipid based	Liposome	Operability, stability, low toxicity. Embedding lipophilic and hydrophilic drug	Drug leakage, easily degraded
	Micelle	Improving the solubility of lipophilic drugs, operability, releasing the drug in a controlled manner	Nonencapsulated hydrophilic drugs, CMC dependency, toxicity
PNP	PLA, PLGA, PCL, chitosan, alginate, gelatin, albumin	Combining hydrophilic and hydrophobic drugs, stability, sustained release	Poor drug loading, toxicity
Exosome		Natural source, biocompatibility, targeting	Low yield, uncertain dose
Inorganic NP	CeO2, MnO2, Pt	Simple to prepare	Toxicity, poor targeting ability