MDR1 Genotypes and Haplotypes Are Closely Associated with Postoperative Fentanyl Consumption in Patients Undergoing Radical Gastrectomy

Table 4

Postoperative fentanyl consumption in different genotypes during the first 24 hours and 48 hours postoperatively.

MDR1 SNPs	Cases	Frequency (%)	Fentanyl dose for 24 hours (μg/kg)	value	Fentanyl dose for 48 hours (μg/kg)	value
1236C>T	135	100
CC	27	20.0	7.4 (6.6-10.1)	0.038^a	14.8 (13.1-17.2)	0.003^b
CT	66	48.9	8.9 (7.0-11.6)		19.1 (15.6-24.7)
TT	42	31.1	10.1 (7.7-15.3)		22.2 (17.6-26.4)
2677G>T/A
GG	33	24.5	8.7 (7.4-10.5)	0.864	18.2 (14.7-21.1)	0.128
GT	37	27.4	8.3 (6.6-13.5)		16.8 (14.1-25.4)
GA	20	14.8	8.4 (6.9-11.5)		16.3 (13.5-21.7)
TA	13	9.6	11.0 (7.5-15.1)		22.0 (18.8-28.3)
TT	25	18.5	9.8 (7.6-15.0)		23.8 (17.9-26.2)
AA	7	5.2	8.4 (6.3-19.1)		14.9 (13.7-29.9)
3435C>T
CC	53	39.3	8.3 (6.9-10.5)	0.575	18.0 (14.0-22.8)	0.176
CT	62	45.9	9.0 (7.0-13.7)		19.6 (14.8-25.1)
TT	20	14.8	9.9 (7.6-15.0)		24.0 (18.7-26.2)

1236C>T: CC: wild type; CT: mutant heterozygote; TT: mutant homozygote. 2677G>T/A: GG: wild type; GT, GA, and TA: mutant heterozygote; TT and AA: mutant homozygote. 3435C>T: CC: wild type; CT: mutant heterozygote; TT: mutant homozygote. ^a,b1236TT genotype carriers received more fentanyl than 1236CC genotype carriers at 24 hours and 48 hours postoperatively.