Research Article
MDR1 Genotypes and Haplotypes Are Closely Associated with Postoperative Fentanyl Consumption in Patients Undergoing Radical Gastrectomy
Table 6
Incidence of nausea, vomiting, and dizziness of 1236C>T, 2677G>T/A, and 3435C>T genotypes and haplotypes.
| | MDR1 | Nausea | value | Vomiting | value | Dizziness | value | | Yes | No | Yes | No | Yes | No |
| | 1236C>T | | | | | | | | | | | CC | 6 (22.2%) | 21 (77.8%) | 0.214 | 7 (25.9%) | 20 (74.1%) | 0.455 | 7 (25.9%) | 20 (74.1%) | 0.825 | | CT | 23 (34.8%) | 43 (65.2%) | 10 (15.2%) | 56 (84.8%) | 17 (25.8%) | 49 (74.2%) | | TT | 18 (42.9%) | 24 (57.1%) | 7 (16.7%) | 35 (83.3%) | 13 (31.0%) | 29 (69.0%) | | 2677G>T/A | | | | | | | | | | | GG | 10 (30.3%) | 23 (69.7%) | 0.449 | 5 (15.2%) | 28 (84.8%) | 0.789 | 7 (21.2%) | 26 (78.8%) | 0.446 | | GT | 13 (35.1%) | 24 (64.9%) | 7 (18.9%) | 30 (81.1%) | 10 (27.0%) | 27 (73.0%) | | GA | 8 (40.0%) | 12 (60.0%) | 5 (25.0%) | 15 (75.0%) | 7 (35.0%) | 13 (65.0%) | | TA | 2 (15.4%) | 11 (84.6%) | 1 (7.7%) | 12 (92.3%) | 2 (15.4%) | 11 (84.6%) | | TT | 12 (48.0%) | 13 (52.0%) | 4 (16.0%) | 21 (84.0%) | 10 (40.0%) | 15 (60.0%) | | AA | 2 (28.6%) | 5 (71.4%) | 2 (28.6%) | 5 (71.4%) | 1 (14.3%) | 6 (85.7%) | | 3435C>T | | | | | | | | | | | CC | 20 (37.7%) | 33 (62.3%) | 0.155 | 11 (20.8%) | 42 (79.2%) | 0.763 | 11 (20.8%) | 42 (79.2%) | 0.240 | | CT | 17 (27.4%) | 45 (72.6%) | 10 (16.1%) | 52 (83.9%) | 18 (29.0%) | 44 (71.0%) | | TT | 10 (50.0%) | 10 (50.0%) | 3 (15.0%) | 17 (85.0%) | 8 (40.0%) | 12 (60.0%) | | Haplotypes | | | | | | | | | | | TTT | 42.5% | 57.5% | 0.128 | 16.1% | 83.9% | 0.302 | 34.5% | 65.5% | 0.178 | | CGC | 30.2% | 69.8% | 15.9% | 84.1% | 31.7% | 68.3% | | CAC | 29.2% | 70.8% | 27.1% | 72.9% | 18.8% | 81.2% | | TGC | 42.6% | 57.4% | 19.1% | 80.9% | 19.1% | 80.9% | | Other | 20.0% | 80.0% | 8.0% | 92.0% | 32.0% | 68.0% |
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