Synthesis of Isatin Derivatives Using Silver Nanoparticles as Green Catalyst: Study of Molecular Docking Interactions in SARS-CoV-2 3c-Like Protease and Determination of Cytotoxic Activities of the Compounds

<div>Synthesis of isatin derivatives. Reagents and conditions: (1) NH<sub>2</sub>NHC=S-NH<sub>2</sub>, EtOH, and AgNPs; (2) CH<sub>2</sub>ClCOOEt, CH<sub>3</sub>COONa, EtOH, and AgNPs; (3a–3n) RCHO, EtOH, and AgNPs.</div>

Journal of Nanomaterials

sch2

Scheme 2

Scheme 2: Synthesis of Isatin Derivatives Using Silver Nanoparticles as Green Catalyst: Study of Molecular Docking Interactions in SARS-CoV-2 3c-Like Protease and Determination of Cytotoxic Activities of the Compounds 

Scheme 2 | Synthesis of Isatin Derivatives Using Silver Nanoparticles as Green Catalyst: Study of Molecular Docking Interactions in SARS-CoV-2 3c-Like Protease and Determination of Cytotoxic Activities of the Compounds 