Synthesis of Isatin Derivatives Using Silver Nanoparticles as Green Catalyst: Study of Molecular Docking Interactions in SARS-CoV-2 3c-Like Protease and Determination of Cytotoxic Activities of the Compounds

Table 1

Optimization of substituent for compounds 3a–3n.

Compounds		Time (hrs)	Yield (%)
3a	PhCHO	3	90
3b	3-NO2PhCHO	3	96
3c	2-OHPhCHO	3	97
3d	4-OHPhCHO	3	95
3e	4-ClPhCHO	3	98
3f	4-OCH3PhCHO	3	94
3g	CH=CH-PhCHO	3	90
3h	Citral	3	93
3i	4-N(CH3)2PhCHO	3	91
3j	Vanillin	3	98
3k	Furfural	3	91
3l	Crotanal	3	89
3m	Glutral	3	92
3n	HCHO	3	87