Research Article

Synthesis of Isatin Derivatives Using Silver Nanoparticles as Green Catalyst: Study of Molecular Docking Interactions in SARS-CoV-2 3c-Like Protease and Determination of Cytotoxic Activities of the Compounds

Table 2

Cytotoxic activity screening of compounds (1, 2, and 3a–3n) against breast cancer cell line (MCF-7) compound in various concentrations (μM).

Cpd. no.10 (μM)25 (μM)50 (μM)100 (μM)IC50 (μM)

164.2
250.0
3a55.1
3b43.4
3c30.1
3d25.3
3e20.5
3f40.7
3g42.8
3h44.6
3i38.7
3j46.0
3k52.3
3l45.9
3m43.7
3n39.0
DOX30.10

NA: compound having ; each value is the mean of .