Synthesis of Isatin Derivatives Using Silver Nanoparticles as Green Catalyst: Study of Molecular Docking Interactions in SARS-CoV-2 3c-Like Protease and Determination of Cytotoxic Activities of the Compounds

Table 3

In vitro cytotoxicity of isatin derivatives (1, 2, and 3a–3n) on normal cells.

Copd. no.	MCF-10A	MRC5
	IC50(μM)	IC50(μM)
1	75.26	70.25
2	63.10	65.87
3a	70.15	73.30
3b	58.31	54.63
3c	73.40	75.45
3d	77.38	80.31
3e	80.06	86.12
3f	56.34	50.08
3g	59.50	54.29
3h	67.14	61.42
3i	52.18	52.84
3j	65.03	67.13
3k	83.26	56.27
3l	78.07	60.52
3m	71.39	58.76
3n	63.02	79.07

Each compound was tested in triplicate. All error bars represent from three independent experiments.